Human health risk assessment

Since 2014, we have assisted with over 60 systematic reviews for federal clients. We cover the life cycle and tailor our approach to the type of review, including searching, screening, extraction, quality review, and synthesis of scientific literature.

Our deep bench of Ph.D. toxicologists determine the quality of studies, weigh the evidence, perform benchmark dose modeling, and develop and implement physiologically-based pharmacokinetic (PBPK) models. They perform risk assessments for a wide range of substances, including hazard identification and dose-response assessment.

We offer support to transition away from animal testing methods through mechanistic analyses, QSAR models, and other in silico methods to understand the hazard potential of chemicals.

Our epidemiologists review, model, and interpret epidemiological evidence to support hazard conclusions and develop quantitative dose-response relationships. We perform meta-analyses and other statistical evaluations to determine the health effects of exposures.

Our exposure assessors use literature data, exposure models, and qualitative understanding to form chemical exposure conclusions for risk assessment. Our computational modelers build, validate, implement, maintain, and modernize the code base of a variety of exposure models, including those relied on for regulatory action.